Endocrinology Case 3 Review Questions

1 . Which one of the following statements is correct regarding thyroid function tests in cats?
Unlike dogs, serious systemic illness has little effect on total T4 levels.
Free T4 may be increased in cats with non-thyroid diseases
TSH assay is the best test to document occult hyperthyroidism
TRH response test is a simple test for occult hyperthyroidism
Total T4 concentrations are increased in about 50% of hyperthyroid cats.

2.Which one of the following statements is correct regarding the pathophysiology of feline hyperthyroidism?
Tachycardia is caused by up-regulation of the parasympathetic nervous system
Hypertension is common
GFR is decreased
Tubular solute load is decreased
TSH levels are increased

3.What one of the following statements is not correct regarding the management of feline hyperthyroidism?
Rapid decreases in thyroxine can worsen azotemia
Beta-blockers can worsen azotemia
Methimazole may cause extreme facial pruritis
Radioiodine causes generalized thyroid gland atrophy
Ipodate blocks the peripheral conversion of T4 to T3

4.IN comparison to cats, which one of the following statements regarding thyroid tumors in dogs is correct?
Common in cats, very rare in dogs
Large tumors in cats, small tumors in dogs
Hyperthyroidism common in both species
Benign in cats, malignant in dogs
Not age specific in either species

5.Which one of the following statements is not correct regarding radioiodine therapy in dogs and cats?
Activity concentrated in active cells
Long half-life requires months of isolation
Radioiodine is excreted in urine and feces
In dogs, surgical debulking improves effect
Higher doses required for adenocarcinomas

6.All of the following are mechanisms for cardiac thyrotoxicosis except?
Pulmonary hypertension
Increased inotrophic effects
Up-regulation of beta receptors
Increased chronotropic effects
Increased myocardial oxygen consumption

7.All of the following are indications for thyroid gland imaging except?
Determine surgical site(s)
Detect ectopic disease
Detect functional metastasis
Determine sensitivity to radioiodine therapy
Detect recurrence following therapy

8.Which of the following is most useful in the evaluation of cardiac thyrotoxicosis?
Thoracic radiographs
Echocardiography
AST, CK concentrations
ECG
Thyroid scan

9.Which one of the following is correct regarding the pharmacological mechanism of methimazole?
Blocks uptake of iodine
Blocks secretion of TSH
Cytotoxic to follicular cells
Blocks polyimerization of iodinated tyrosine
Inhibits degradation of colloid

10.All of the following create systemic hypertension in dogs and cats except?
Hyperadrenocorticism
Hyperthyroidism
Acromegaly
Renal failure
Hypoadrenocorticism