Endocrinology Case 11 Review Questions

1 . Which one of the following is NOT an effect of insulin?
Facilitates transport of glucose into cells except neurons, RBC's, intestinal mucosa, and renal tubular epithelium.
Promotes glucose trapping in hepatocytes.
Promotes glycogen storage in liver.
Inhibits lipoprotein lipase
Inhibits protein synthesis

2.All of the following are anti-inuslin or hyperglycemic hormones EXCEPT?
Progesterone
Vasopressin
Glucagon
Epinephrine
Thyroxine

3.Which of the following statements is NOT correct regarding the control of insulin?
Insulin release is controlled by concentration of glucose in beta cells.
Certain amino acids are potent stimulators of insulin release.
At a blood sugar of 50 mg/dl, insulin release should cease.
At a blood glucose od 110-120 mg/dl, insulin secretion should increase.
Secretin and cholecystokinin promote insulin secretion.

4.Which one of the following risk factors is most important in the development of DM in cats?
Hereditary
Obesity
High carbohydrate diet
Infection
Concurrent disease

5.Which one of the following is NOT CORRECT regarding the pathophysiology of diabetic ketoacidosis?
Stress hormones are an important component
Underlying infection is commonly present
Relative insulin resistance is present
Increased activity in glycolytic pathway is a key feature
Hepatic ketone production is increased

6.Which answer is INCORRECT regarding the diagnosis or laboratory findings in DKA?
Urine specific gravity is usually 1.018-1.028.
Hypernatremia indicates free water loss.
Potassium depletion is common.
Azotemia is commonly present.
Hyperphosphatemia is common.

7.Which one of the following represents the best treatment for a dog with diabetic ketoacidosis, a blood glucose of 425 mg/dl, serum sodium of 134, serum potassium of 3.2, and TCO2 of 13?
Regular insulin, lactated Ringers, sodium bicarbonate
NPH insulin, normal saline, potassium
Regular insulin, normal saline, potassium
Regular insulin, normal saline, sodium bicarbonate
NPH insulin, lactated Ringers, potassium

8.In the management of DKA, which one of the following statements is NOT correct?
Regular insulin inhibits lipolysis and hepatic glucose production,
Blood glucose should decrease by 50-100 mg/dl/hour
Rapid reduction in blood glucose produces cerebral edema.
A decreasing blood sugar is associated with ketone metabolism
Regular insulin therapy is not stopped until the blood sugar is in the normal range.

9.Which one of the following statements best describes the Somoygi phenomenon?
Hyperglycemia caused by under-dosing insulin
Rebound hyperglycemia from feeding too much simple carbohydrates.
Most commonly occurs 18-20 hours after insulin therapy
Hyperglycemic effect caused by over-dosing insulin
Hypoglycemia found 18-20 hours after insulin therapy

10.The most common form of diabetes mellitus in dogs is?
Type 1
Type 2
Type 3
Insulin resistant
Type 4

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